Drug interactions
Amisulpride + Valbenazine
Severity: Major
Amisulpride and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amisulpride and valbenazine can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia, or other QT-prolonging drugs. Valbenazine is also associated with somnolence, which may be additive.
What this interaction means in plain words
Amisulpride and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and monitor QTc if the combination is needed. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
- Cisapride + Valbenazine Major
Frequently asked questions
Can I take Amisulpride with Valbenazine?
MediHelp rates the interaction as major. Amisulpride and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both amisulpride and valbenazine can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia, or other QT-prolonging drugs. Valbenazine is also associated with somnolence, which may be additive.
How serious is the interaction between Amisulpride and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc if the combination is needed. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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