Drug interactions
Atorvastatin + Darolutamide
Severity: Moderate
Atorvastatin and Darolutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, which can increase exposure to atorvastatin. Higher statin levels may raise the risk of muscle toxicity.
What this interaction means in plain words
Atorvastatin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Darolutamide belongs to Miscellaneous.
Why it happens
Darolutamide inhibits BCRP (and OATP1B) transport, raising atorvastatin concentrations.
What to do
Monitor for myopathy and consider reducing the atorvastatin dose during darolutamide therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Atorvastatin with Darolutamide?
MediHelp rates the interaction as moderate. Atorvastatin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, which can increase exposure to atorvastatin. Higher statin levels may raise the risk of muscle toxicity.
How serious is the interaction between Atorvastatin and Darolutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy and consider reducing the atorvastatin dose during darolutamide therapy.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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