Drug interactions
Atorvastatin + Darunavir
Severity: Major
Atorvastatin and Darunavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and increases atorvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Atorvastatin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atorvastatin belongs to Cardiovascular; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated atorvastatin metabolism by boosted darunavir.
What to do
Start with the lowest atorvastatin dose and keep it at or below 20 mg daily. Monitor for muscle symptoms and CK.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Atorvastatin with Darunavir?
MediHelp rates the interaction as major. Atorvastatin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and increases atorvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Atorvastatin and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest atorvastatin dose and keep it at or below 20 mg daily. Monitor for muscle symptoms and CK.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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