Drug interactions
Atorvastatin + Dronedarone
Severity: Moderate
Atorvastatin and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can increase atorvastatin concentrations, raising the risk of myopathy and, rarely, rhabdomyolysis.
What this interaction means in plain words
Atorvastatin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, reducing atorvastatin metabolism and efflux.
What to do
Use the lowest effective atorvastatin dose and counsel the patient to report muscle pain or weakness. Check creatine kinase if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Dronedarone?
MediHelp rates the interaction as moderate. Atorvastatin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can increase atorvastatin concentrations, raising the risk of myopathy and, rarely, rhabdomyolysis.
How serious is the interaction between Atorvastatin and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and counsel the patient to report muscle pain or weakness. Check creatine kinase if symptoms occur.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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