Drug interactions
Atorvastatin + Edoxaban
Severity: Minor
Atorvastatin and Edoxaban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is a weak P-gp inhibitor and may slightly raise edoxaban levels. This is rarely clinically significant.
What this interaction means in plain words
Atorvastatin and Edoxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Weak inhibition of P-glycoprotein efflux increases edoxaban exposure slightly.
What to do
No dose adjustment is needed; continue routine bleeding surveillance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Edoxaban?
MediHelp rates the interaction as minor. Atorvastatin and Edoxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is a weak P-gp inhibitor and may slightly raise edoxaban levels. This is rarely clinically significant.
How serious is the interaction between Atorvastatin and Edoxaban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine bleeding surveillance.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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