Drug interactions
Atorvastatin + Eliglustat
Severity: Moderate
Atorvastatin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise atorvastatin concentrations. This could increase statin-related adverse effects such as myopathy.
What this interaction means in plain words
Atorvastatin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by eliglustat reduces atorvastatin efflux, increasing exposure.
What to do
Monitor for muscle symptoms and consider a reduced atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Atorvastatin with Eliglustat?
MediHelp rates the interaction as moderate. Atorvastatin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and may raise atorvastatin concentrations. This could increase statin-related adverse effects such as myopathy.
How serious is the interaction between Atorvastatin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider a reduced atorvastatin dose.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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