Drug interactions
Atorvastatin + Eluxadoline
Severity: Moderate
Atorvastatin and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin inhibits OATP1B1, which can raise eluxadoline concentrations. Higher eluxadoline exposure may increase its adverse effects, including constipation, nausea and pancreatitis risk.
What this interaction means in plain words
Atorvastatin and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
OATP1B1 inhibition by atorvastatin reduces hepatic uptake of eluxadoline.
What to do
Reduce eluxadoline to 75 mg twice daily with OATP1B1 inhibitors, and monitor for abdominal pain, constipation and nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Atorvastatin with Eluxadoline?
MediHelp rates the interaction as moderate. Atorvastatin and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atorvastatin inhibits OATP1B1, which can raise eluxadoline concentrations. Higher eluxadoline exposure may increase its adverse effects, including constipation, nausea and pancreatitis risk.
How serious is the interaction between Atorvastatin and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily with OATP1B1 inhibitors, and monitor for abdominal pain, constipation and nausea.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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