Drug interactions
Atorvastatin + Fosaprepitant
Severity: Minor
Atorvastatin and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, a prodrug of aprepitant, is a weak-to-moderate CYP3A4 inhibitor and may transiently raise atorvastatin levels after single-dose use. Clinical significance is small for short courses.
What this interaction means in plain words
Atorvastatin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant temporarily inhibits CYP3A4, reducing atorvastatin metabolism.
What to do
No dose change is usually needed for a single dose; counsel the patient to report muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Atorvastatin with Fosaprepitant?
MediHelp rates the interaction as minor. Atorvastatin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, a prodrug of aprepitant, is a weak-to-moderate CYP3A4 inhibitor and may transiently raise atorvastatin levels after single-dose use. Clinical significance is small for short courses.
How serious is the interaction between Atorvastatin and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for a single dose; counsel the patient to report muscle symptoms.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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