Drug interactions
Atorvastatin + Ivacaftor
Severity: Moderate
Atorvastatin and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite can inhibit P-glycoprotein, which may modestly increase atorvastatin exposure. This could add to the risk of statin-related muscle toxicity.
What this interaction means in plain words
Atorvastatin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor inhibits intestinal P-glycoprotein efflux, increasing atorvastatin absorption.
What to do
Monitor for myalgia and weakness, and check CK if symptoms arise. Use the lowest effective atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Atorvastatin with Ivacaftor?
MediHelp rates the interaction as moderate. Atorvastatin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its M1 metabolite can inhibit P-glycoprotein, which may modestly increase atorvastatin exposure. This could add to the risk of statin-related muscle toxicity.
How serious is the interaction between Atorvastatin and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and weakness, and check CK if symptoms arise. Use the lowest effective atorvastatin dose.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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