Drug interactions
Atorvastatin + Midazolam
Severity: Minor
Atorvastatin and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is a substrate of CYP3A4 and has little meaningful inhibitory effect on it, so any rise in midazolam exposure is small. Clinically relevant prolongation of sedation is unlikely.
What this interaction means in plain words
Atorvastatin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
Possible minor competition for CYP3A4 metabolism; no established inhibitory effect.
What to do
No dose adjustment is needed; use standard sedation monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Midazolam?
MediHelp rates the interaction as minor. Atorvastatin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is a substrate of CYP3A4 and has little meaningful inhibitory effect on it, so any rise in midazolam exposure is small. Clinically relevant prolongation of sedation is unlikely.
How serious is the interaction between Atorvastatin and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use standard sedation monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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