Drug interactions
Atorvastatin + Paliperidone
Severity: Minor
Atorvastatin and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are P-glycoprotein substrates, and atorvastatin is a weak inhibitor of this transporter. A clinically relevant rise in paliperidone exposure is unlikely.
What this interaction means in plain words
Atorvastatin and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Paliperidone belongs to Central Nervous System.
Why it happens
Possible weak P-glycoprotein inhibition by atorvastatin.
What to do
No dose adjustment is required. Monitor for the usual paliperidone adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Atorvastatin with Paliperidone?
MediHelp rates the interaction as minor. Atorvastatin and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are P-glycoprotein substrates, and atorvastatin is a weak inhibitor of this transporter. A clinically relevant rise in paliperidone exposure is unlikely.
How serious is the interaction between Atorvastatin and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for the usual paliperidone adverse effects.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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