Drug interactions
Atorvastatin + Tazemetostat
Severity: Minor
Atorvastatin and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower atorvastatin concentrations, potentially reducing lipid-lowering effect. Atorvastatin is not expected to meaningfully change tazemetostat exposure. The effect is usually small.
What this interaction means in plain words
Atorvastatin and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4, increasing the metabolism of atorvastatin.
What to do
Monitor lipid profile during co-treatment and adjust the atorvastatin dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Atorvastatin with Tazemetostat?
MediHelp rates the interaction as minor. Atorvastatin and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may lower atorvastatin concentrations, potentially reducing lipid-lowering effect. Atorvastatin is not expected to meaningfully change tazemetostat exposure. The effect is usually small.
How serious is the interaction between Atorvastatin and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid profile during co-treatment and adjust the atorvastatin dose if the response is inadequate.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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