Drug interactions
Atovaquone-proguanil + Indinavir
Severity: Minor
Atovaquone-proguanil and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may modestly reduce atovaquone concentrations, which could weaken antimalarial protection. The effect is poorly characterized and probably small.
What this interaction means in plain words
Atovaquone-proguanil and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established.
What to do
No dose change is usually needed; reinforce adherence and bite-prevention measures and consider alternative prophylaxis in high-risk areas.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atovaquone-proguanil
Frequently asked questions
Can I take Atovaquone-proguanil with Indinavir?
MediHelp rates the interaction as minor. Atovaquone-proguanil and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir may modestly reduce atovaquone concentrations, which could weaken antimalarial protection. The effect is poorly characterized and probably small.
How serious is the interaction between Atovaquone-proguanil and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; reinforce adherence and bite-prevention measures and consider alternative prophylaxis in high-risk areas.
What other medicines interact with Atovaquone-proguanil?
MediHelp also lists interactions of Atovaquone-proguanil with, for example, Efavirenz, Metoclopramide, Tetracycline. The full list is on the Atovaquone-proguanil page.
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