Drug interactions
Atovaquone-proguanil + Metoclopramide intranasal
Severity: Minor
Atovaquone-proguanil and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has been reported to lower atovaquone plasma levels, likely through effects on gut motility. This might reduce antimalarial efficacy, particularly when used for prophylaxis or treatment.
What this interaction means in plain words
Atovaquone-proguanil and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Altered gastrointestinal motility may reduce atovaquone absorption.
What to do
Monitor for reduced response and prefer an alternative antiemetic when treating malaria; take atovaquone-proguanil with fatty food.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atovaquone-proguanil
Frequently asked questions
Can I take Atovaquone-proguanil with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Atovaquone-proguanil and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide has been reported to lower atovaquone plasma levels, likely through effects on gut motility. This might reduce antimalarial efficacy, particularly when used for prophylaxis or treatment.
How serious is the interaction between Atovaquone-proguanil and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and prefer an alternative antiemetic when treating malaria; take atovaquone-proguanil with fatty food.
What other medicines interact with Atovaquone-proguanil?
MediHelp also lists interactions of Atovaquone-proguanil with, for example, Efavirenz, Metoclopramide, Tetracycline. The full list is on the Atovaquone-proguanil page.
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