Drug interactions
Atovaquone-proguanil + Tetracycline
Severity: Moderate
Atovaquone-proguanil and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline has been reported to lower plasma atovaquone concentrations when the two are given together. Reduced atovaquone exposure could weaken antimalarial prophylaxis or treatment efficacy.
What this interaction means in plain words
Atovaquone-proguanil and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atovaquone-proguanil belongs to Anti Parasitic; Tetracycline belongs to Anti Bacterial.
Why it happens
The mechanism is not well established; reduced atovaquone exposure has been observed, possibly through altered absorption or disposition.
What to do
Avoid the combination where an alternative antibiotic is suitable. If both are required, monitor for parasitological response and consider checking for treatment failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atovaquone-proguanil
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Atovaquone-proguanil with Tetracycline?
MediHelp rates the interaction as moderate. Atovaquone-proguanil and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracycline has been reported to lower plasma atovaquone concentrations when the two are given together. Reduced atovaquone exposure could weaken antimalarial prophylaxis or treatment efficacy.
How serious is the interaction between Atovaquone-proguanil and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic is suitable. If both are required, monitor for parasitological response and consider checking for treatment failure.
What other medicines interact with Atovaquone-proguanil?
MediHelp also lists interactions of Atovaquone-proguanil with, for example, Efavirenz, Metoclopramide, Indinavir. The full list is on the Atovaquone-proguanil page.
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