Drug interactions
Atovaquone-proguanil + Metoclopramide
Severity: Moderate
Atovaquone-proguanil and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has been reported to lower atovaquone plasma concentrations. Reduced atovaquone exposure could compromise malaria prophylaxis or treatment efficacy.
What this interaction means in plain words
Atovaquone-proguanil and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atovaquone-proguanil belongs to Anti Parasitic; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Metoclopramide increases gastric motility, which may reduce atovaquone absorption; the exact mechanism is not firmly established.
What to do
Use another antiemetic where possible. If metoclopramide is needed in malaria treatment, monitor parasitological response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atovaquone-proguanil
Other interactions of Metoclopramide
Frequently asked questions
Can I take Atovaquone-proguanil with Metoclopramide?
MediHelp rates the interaction as moderate. Atovaquone-proguanil and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has been reported to lower atovaquone plasma concentrations. Reduced atovaquone exposure could compromise malaria prophylaxis or treatment efficacy.
How serious is the interaction between Atovaquone-proguanil and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use another antiemetic where possible. If metoclopramide is needed in malaria treatment, monitor parasitological response.
What other medicines interact with Atovaquone-proguanil?
MediHelp also lists interactions of Atovaquone-proguanil with, for example, Efavirenz, Tetracycline, Indinavir. The full list is on the Atovaquone-proguanil page.
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