Drug interactions
Atracurium + Paromomycin
Severity: Moderate
Atracurium and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, but systemic uptake may occur with intestinal inflammation or renal impairment, and aminoglycosides can potentiate neuromuscular blockers. Prolonged paralysis or apnea is possible.
What this interaction means in plain words
Atracurium and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside effect on acetylcholine release and receptor sensitivity adds to nondepolarizing blockade.
What to do
Monitor neuromuscular function and renal function, and reduce atracurium dosing if blockade is prolonged. Maintain ventilatory support until recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
- Bumetanide + Paromomycin Moderate
Frequently asked questions
Can I take Atracurium with Paromomycin?
MediHelp rates the interaction as moderate. Atracurium and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is minimally absorbed, but systemic uptake may occur with intestinal inflammation or renal impairment, and aminoglycosides can potentiate neuromuscular blockers. Prolonged paralysis or apnea is possible.
How serious is the interaction between Atracurium and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function and renal function, and reduce atracurium dosing if blockade is prolonged. Maintain ventilatory support until recovery.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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