Drug interactions
Bumetanide + Paromomycin
Severity: Moderate
Bumetanide and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is an aminoglycoside with minimal oral absorption, which can increase with intestinal ulceration or renal impairment. In that case combined use with a loop diuretic may add ototoxic and nephrotoxic risk.
What this interaction means in plain words
Bumetanide and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Paromomycin belongs to Anti Bacterial.
Why it happens
Potential additive ototoxicity and nephrotoxicity if systemic aminoglycoside absorption occurs.
What to do
Monitor renal function and hearing in patients with renal impairment or GI mucosal damage.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bumetanide and Paromomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bumetanide
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Bumetanide with Paromomycin?
MediHelp rates the interaction as moderate. Bumetanide and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paromomycin is an aminoglycoside with minimal oral absorption, which can increase with intestinal ulceration or renal impairment. In that case combined use with a loop diuretic may add ototoxic and nephrotoxic risk.
How serious is the interaction between Bumetanide and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing in patients with renal impairment or GI mucosal damage.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
