Drug interactions
Cidofovir + Paromomycin
Severity: Major
Cidofovir and Paromomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cidofovir is nephrotoxic, and paromomycin, an aminoglycoside, can be absorbed systemically, especially with impaired gut mucosa or renal impairment, causing nephrotoxicity and ototoxicity. Combined use may increase kidney injury risk.
What this interaction means in plain words
Cidofovir and Paromomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cidofovir belongs to Anti Virals; Paromomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with potential additive ototoxicity from systemically absorbed aminoglycoside.
What to do
Avoid concurrent use where possible and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and urine protein before each cidofovir dose and ensure hydration and probenecid.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Paromomycin
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
- Bumetanide + Paromomycin Moderate
Frequently asked questions
Can I take Cidofovir with Paromomycin?
MediHelp rates the interaction as major. Cidofovir and Paromomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cidofovir is nephrotoxic, and paromomycin, an aminoglycoside, can be absorbed systemically, especially with impaired gut mucosa or renal impairment, causing nephrotoxicity and ototoxicity. Combined use may increase kidney injury risk.
How serious is the interaction between Cidofovir and Paromomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and urine protein before each cidofovir dose and ensure hydration and probenecid.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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