Drug interactions
Bacitracin-neomycin-polymyxin + Paromomycin
Severity: Moderate
Bacitracin-neomycin-polymyxin and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin and neomycin are both aminoglycosides, and polymyxin B is also nephrotoxic and ototoxic. Paromomycin is poorly absorbed orally, but absorption can rise with bowel inflammation or renal impairment, and absorbed topical antibiotic from large wounds adds to the risk.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Paromomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity from aminoglycoside and polymyxin exposure.
What to do
Limit topical use to small areas of intact skin during paromomycin therapy. Monitor renal function and hearing if either agent is substantially absorbed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bacitracin-neomycin-polymyxin and Paromomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bumetanide + Paromomycin Moderate
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Paromomycin?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paromomycin and neomycin are both aminoglycosides, and polymyxin B is also nephrotoxic and ototoxic. Paromomycin is poorly absorbed orally, but absorption can rise with bowel inflammation or renal impairment, and absorbed topical antibiotic from large wounds adds to the risk.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit topical use to small areas of intact skin during paromomycin therapy. Monitor renal function and hearing if either agent is substantially absorbed.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
