Drug interactions
Amphotericin b + Paromomycin
Severity: Moderate
Amphotericin b and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is poorly absorbed, so systemic nephrotoxicity is limited unless absorption is increased, for instance with bowel damage or renal impairment. Parenteral aminoglycoside-like toxicity may add to amphotericin B kidney injury in those settings.
What this interaction means in plain words
Amphotericin b and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Paromomycin belongs to Anti Bacterial.
Why it happens
Potential additive nephrotoxicity and ototoxicity when paromomycin is systemically absorbed.
What to do
Monitor renal function and electrolytes during combined therapy, especially with impaired renal function or intestinal inflammation. Consider alternatives if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
- Bumetanide + Paromomycin Moderate
Frequently asked questions
Can I take Amphotericin b with Paromomycin?
MediHelp rates the interaction as moderate. Amphotericin b and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is poorly absorbed, so systemic nephrotoxicity is limited unless absorption is increased, for instance with bowel damage or renal impairment. Parenteral aminoglycoside-like toxicity may add to amphotericin B kidney injury in those settings.
How serious is the interaction between Amphotericin b and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and electrolytes during combined therapy, especially with impaired renal function or intestinal inflammation. Consider alternatives if renal function declines.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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