Drug interactions
Atracurium + Sevoflurane
Severity: Moderate
Atracurium and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane potentiate nondepolarizing neuromuscular blockers, increasing the depth and duration of block. Atracurium requirements are therefore lower during sevoflurane anesthesia.
What this interaction means in plain words
Atracurium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Sevoflurane depresses postjunctional neuromuscular transmission and sensitizes the receptor to nondepolarizing blockade.
What to do
Reduce atracurium doses and titrate to train-of-four response. Ensure adequate recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Sevoflurane
Frequently asked questions
Can I take Atracurium with Sevoflurane?
MediHelp rates the interaction as moderate. Atracurium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane potentiate nondepolarizing neuromuscular blockers, increasing the depth and duration of block. Atracurium requirements are therefore lower during sevoflurane anesthesia.
How serious is the interaction between Atracurium and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce atracurium doses and titrate to train-of-four response. Ensure adequate recovery before extubation.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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