Drug interactions
Atropine + Cyclizine
Severity: Moderate
Atropine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic activity that adds to atropine's effects. Combined use may cause dry mouth, blurred vision, constipation, urinary retention, tachycardia and confusion, especially in older patients.
What this interaction means in plain words
Atropine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Cyclizine belongs to Respiratory.
Why it happens
Additive antagonism of muscarinic receptors.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation, tachycardia and confusion. Reduce doses or choose a non-anticholinergic antiemetic in vulnerable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Atropine with Cyclizine?
MediHelp rates the interaction as moderate. Atropine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic activity that adds to atropine's effects. Combined use may cause dry mouth, blurred vision, constipation, urinary retention, tachycardia and confusion, especially in older patients.
How serious is the interaction between Atropine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation, tachycardia and confusion. Reduce doses or choose a non-anticholinergic antiemetic in vulnerable patients.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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