Drug interactions
Atropine + Oliceridine
Severity: Moderate
Atropine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gut motility and can cause urinary retention, and atropine adds to these effects. The combination raises the risk of severe constipation, paralytic ileus and urinary retention.
What this interaction means in plain words
Atropine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive reduction in gastrointestinal and bladder motility via opioid receptor agonism and muscarinic blockade.
What to do
Monitor for urinary retention, abdominal distension and reduced bowel sounds, and use a bowel regimen. Reduce or stop the anticholinergic if ileus signs develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Atropine with Oliceridine?
MediHelp rates the interaction as moderate. Atropine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gut motility and can cause urinary retention, and atropine adds to these effects. The combination raises the risk of severe constipation, paralytic ileus and urinary retention.
How serious is the interaction between Atropine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, abdominal distension and reduced bowel sounds, and use a bowel regimen. Reduce or stop the anticholinergic if ileus signs develop.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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