Drug interactions
Avacopan + Upadacitinib
Severity: Moderate
Avacopan and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avacopan is used with other immunosuppressants in ANCA vasculitis and adds to infection risk. Combined with upadacitinib, the risk of serious infection may increase, though the interaction is mainly theoretical.
What this interaction means in plain words
Avacopan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avacopan belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from C5a receptor antagonism and JAK inhibition.
What to do
Monitor for signs of infection and screen for hepatitis B before treatment. Review the need for both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Avacopan with Upadacitinib?
MediHelp rates the interaction as moderate. Avacopan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avacopan is used with other immunosuppressants in ANCA vasculitis and adds to infection risk. Combined with upadacitinib, the risk of serious infection may increase, though the interaction is mainly theoretical.
How serious is the interaction between Avacopan and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for hepatitis B before treatment. Review the need for both agents.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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