Drug interactions
Avapritinib + Clonazepam
Severity: Moderate
Avapritinib and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the sedation caused by clonazepam. Patients may have more memory impairment, confusion or drowsiness.
What this interaction means in plain words
Avapritinib and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Clonazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system effects; avapritinib has CNS adverse effects of its own.
What to do
Monitor for cognitive changes and sedation, and consider lowering the clonazepam dose if symptoms appear. Interrupt or reduce avapritinib per labeling if significant cognitive effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Clonazepam?
MediHelp rates the interaction as moderate. Avapritinib and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the sedation caused by clonazepam. Patients may have more memory impairment, confusion or drowsiness.
How serious is the interaction between Avapritinib and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes and sedation, and consider lowering the clonazepam dose if symptoms appear. Interrupt or reduce avapritinib per labeling if significant cognitive effects occur.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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