Drug interactions
Avapritinib + Clozapine
Severity: Moderate
Avapritinib and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and clozapine is strongly sedating. Together they may increase drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Clozapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and cognitive changes and counsel about driving and hazardous activities. Reduce or hold avapritinib per labeling if cognitive adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Clozapine?
MediHelp rates the interaction as moderate. Avapritinib and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and clozapine is strongly sedating. Together they may increase drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and counsel about driving and hazardous activities. Reduce or hold avapritinib per labeling if cognitive adverse effects develop.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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