Drug interactions
Avapritinib + Codeine
Severity: Moderate
Avapritinib and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as confusion, memory impairment and somnolence. Combined with an opioid like codeine, central nervous system depression and psychomotor impairment may be greater than with either drug alone.
What this interaction means in plain words
Avapritinib and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Codeine belongs to Musculoskeletal.
Why it happens
Additive central nervous system effects; avapritinib neurocognitive toxicity combined with opioid-induced sedation.
What to do
Monitor for excessive sedation, confusion and cognitive decline, and use the lowest effective codeine dose. Counsel the patient about driving and operating machinery, and reduce or stop either drug if neurocognitive symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Codeine?
MediHelp rates the interaction as moderate. Avapritinib and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as confusion, memory impairment and somnolence. Combined with an opioid like codeine, central nervous system depression and psychomotor impairment may be greater than with either drug alone.
How serious is the interaction between Avapritinib and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and cognitive decline, and use the lowest effective codeine dose. Counsel the patient about driving and operating machinery, and reduce or stop either drug if neurocognitive symptoms worsen.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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