Drug interactions
Avapritinib + Cyclosporin
Severity: Major
Avapritinib and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and may increase avapritinib exposure, raising the risk of cognitive effects, intracranial hemorrhage, edema and other toxicities.
What this interaction means in plain words
Avapritinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib.
What to do
Avoid combining if possible. If unavoidable, reduce the avapritinib starting dose as labeled and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Cyclosporin?
MediHelp rates the interaction as major. Avapritinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and may increase avapritinib exposure, raising the risk of cognitive effects, intracranial hemorrhage, edema and other toxicities.
How serious is the interaction between Avapritinib and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible. If unavoidable, reduce the avapritinib starting dose as labeled and monitor for adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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