Drug interactions
Avapritinib + Diphenoxylate-atropine
Severity: Moderate
Avapritinib and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and diphenoxylate is an opioid that can be sedating, especially in overdose or in susceptible patients. Together they may increase drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS effects; this is a pharmacodynamic prediction without a well-defined interaction mechanism.
What to do
Monitor for worsening somnolence, confusion or memory impairment. Advise against driving, and use the lowest effective antidiarrheal dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Avapritinib and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and diphenoxylate is an opioid that can be sedating, especially in overdose or in susceptible patients. Together they may increase drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening somnolence, confusion or memory impairment. Advise against driving, and use the lowest effective antidiarrheal dose.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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