Drug interactions
Avapritinib + Docetaxel
Severity: Minor
Avapritinib and Docetaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is not a recognized CYP3A4 inhibitor, so a meaningful rise in avapritinib exposure is unlikely. Overlapping myelosuppression and other toxicities remain possible.
What this interaction means in plain words
Avapritinib and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Docetaxel belongs to Oncology.
Why it happens
No established pharmacokinetic mechanism; the CYP3A4 effect is theoretical.
What to do
Monitor blood counts and avapritinib tolerability. No dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Docetaxel?
MediHelp rates the interaction as minor. Avapritinib and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Docetaxel is not a recognized CYP3A4 inhibitor, so a meaningful rise in avapritinib exposure is unlikely. Overlapping myelosuppression and other toxicities remain possible.
How serious is the interaction between Avapritinib and Docetaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and avapritinib tolerability. No dose change is needed.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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