Drug interactions
Avapritinib + Doxylamine
Severity: Moderate
Avapritinib and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and doxylamine adds sedating antihistamine effects. Combined use may worsen drowsiness, confusion and memory problems.
What this interaction means in plain words
Avapritinib and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depressant effects; the mechanism of avapritinib's CNS effects is not fully established.
What to do
Monitor for cognitive impairment and sedation. Consider a non-sedating alternative to doxylamine if CNS effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Doxylamine?
MediHelp rates the interaction as moderate. Avapritinib and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and doxylamine adds sedating antihistamine effects. Combined use may worsen drowsiness, confusion and memory problems.
How serious is the interaction between Avapritinib and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive impairment and sedation. Consider a non-sedating alternative to doxylamine if CNS effects emerge.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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