Drug interactions
Avapritinib + Efavirenz
Severity: Major
Avapritinib and Efavirenz: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz, a CYP3A4 inducer, can markedly reduce avapritinib exposure and efficacy. Both drugs also have CNS effects that may add to sedation or cognitive symptoms.
What this interaction means in plain words
Avapritinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing avapritinib clearance, with additive CNS effects.
What to do
Avoid concomitant use with moderate or strong CYP3A4 inducers per labeling and choose an alternative antiretroviral.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Efavirenz?
MediHelp rates the interaction as major. Avapritinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz, a CYP3A4 inducer, can markedly reduce avapritinib exposure and efficacy. Both drugs also have CNS effects that may add to sedation or cognitive symptoms.
How serious is the interaction between Avapritinib and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with moderate or strong CYP3A4 inducers per labeling and choose an alternative antiretroviral.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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