Drug interactions
Avapritinib + Erythromycin
Severity: Major
Avapritinib and Erythromycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin, a moderate CYP3A4 inhibitor, can raise avapritinib concentrations and increase the risk of adverse effects such as cognitive effects, intracranial hemorrhage and edema. Labeling advises avoiding moderate CYP3A4 inhibitors.
What this interaction means in plain words
Avapritinib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated avapritinib metabolism by erythromycin.
What to do
Use a non-CYP3A4-inhibiting antibiotic instead. If it cannot be avoided, reduce the avapritinib dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Erythromycin?
MediHelp rates the interaction as major. Avapritinib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin, a moderate CYP3A4 inhibitor, can raise avapritinib concentrations and increase the risk of adverse effects such as cognitive effects, intracranial hemorrhage and edema. Labeling advises avoiding moderate CYP3A4 inhibitors.
How serious is the interaction between Avapritinib and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic instead. If it cannot be avoided, reduce the avapritinib dose per labeling and monitor for toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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