Drug interactions
Avapritinib + Imipramine
Severity: Moderate
Avapritinib and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS effects, so combining them may increase drowsiness, cognitive slowing and impaired psychomotor performance. Avapritinib is also associated with cognitive adverse effects and memory impairment.
What this interaction means in plain words
Avapritinib and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects; no established pharmacokinetic mechanism.
What to do
Monitor for excessive sedation and cognitive changes, and advise patients to avoid driving or hazardous tasks until response is known. Reduce the imipramine dose or review therapy if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Imipramine?
MediHelp rates the interaction as moderate. Avapritinib and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause CNS effects, so combining them may increase drowsiness, cognitive slowing and impaired psychomotor performance. Avapritinib is also associated with cognitive adverse effects and memory impairment.
How serious is the interaction between Avapritinib and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive changes, and advise patients to avoid driving or hazardous tasks until response is known. Reduce the imipramine dose or review therapy if cognitive effects emerge.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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