Drug interactions
Avapritinib + Isoflurane
Severity: Minor
Avapritinib and Isoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may be additive with general anesthetics. Recovery from anesthesia may be prolonged or more confused.
What this interaction means in plain words
Avapritinib and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Isoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; the avapritinib effect on the CNS is not well established.
What to do
Make the anesthesia team aware of avapritinib use and monitor postoperative sedation and cognition.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoflurane
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Isoflurane?
MediHelp rates the interaction as minor. Avapritinib and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib can cause cognitive effects and somnolence, which may be additive with general anesthetics. Recovery from anesthesia may be prolonged or more confused.
How serious is the interaction between Avapritinib and Isoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Make the anesthesia team aware of avapritinib use and monitor postoperative sedation and cognition.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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