Drug interactions
Avapritinib + Methadone
Severity: Moderate
Avapritinib and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and methadone adds CNS depression. The combination may cause excess sedation, confusion and respiratory depression.
What this interaction means in plain words
Avapritinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective methadone dose and monitor for sedation, cognitive changes and respiratory depression. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Methadone?
MediHelp rates the interaction as moderate. Avapritinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and methadone adds CNS depression. The combination may cause excess sedation, confusion and respiratory depression.
How serious is the interaction between Avapritinib and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective methadone dose and monitor for sedation, cognitive changes and respiratory depression. Counsel patients on driving and operating machinery.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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