Drug interactions
Avapritinib + Morphine
Severity: Moderate
Avapritinib and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and morphine adds CNS depression. The combination can increase sedation and impair alertness.
What this interaction means in plain words
Avapritinib and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; the avapritinib neurocognitive mechanism is not fully defined.
What to do
Use the lowest effective morphine dose and monitor for sedation and cognitive changes. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Morphine?
MediHelp rates the interaction as moderate. Avapritinib and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and morphine adds CNS depression. The combination can increase sedation and impair alertness.
How serious is the interaction between Avapritinib and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective morphine dose and monitor for sedation and cognitive changes. Counsel patients on driving and operating machinery.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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