Drug interactions
Avapritinib + Nilotinib
Severity: Major
Avapritinib and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may raise avapritinib exposure through CYP3A4 inhibition. Avapritinib is associated with intracranial hemorrhage, cognitive effects and QT concerns, so higher exposure is undesirable, and nilotinib itself prolongs QT.
What this interaction means in plain words
Avapritinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by nilotinib increases avapritinib levels, with possible additive QT effects.
What to do
Avoid the combination if possible. If it is necessary, follow avapritinib labeling for dose reduction with CYP3A4 inhibitors and monitor ECG and neurological status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Nilotinib?
MediHelp rates the interaction as major. Avapritinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib may raise avapritinib exposure through CYP3A4 inhibition. Avapritinib is associated with intracranial hemorrhage, cognitive effects and QT concerns, so higher exposure is undesirable, and nilotinib itself prolongs QT.
How serious is the interaction between Avapritinib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is necessary, follow avapritinib labeling for dose reduction with CYP3A4 inhibitors and monitor ECG and neurological status.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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