Drug interactions
Avapritinib + Oxazepam
Severity: Moderate
Avapritinib and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and combining it with a benzodiazepine may intensify drowsiness and impaired concentration. This is mainly a concern in patients already showing cognitive adverse effects.
What this interaction means in plain words
Avapritinib and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS effects; oxazepam enhances GABA-A activity while avapritinib has its own CNS adverse effects.
What to do
Monitor for sedation and cognitive changes, and reduce or stop oxazepam if cognitive impairment appears. Avoid driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Oxazepam?
MediHelp rates the interaction as moderate. Avapritinib and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and combining it with a benzodiazepine may intensify drowsiness and impaired concentration. This is mainly a concern in patients already showing cognitive adverse effects.
How serious is the interaction between Avapritinib and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and reduce or stop oxazepam if cognitive impairment appears. Avoid driving until the combined effect is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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