Drug interactions
Avapritinib + Pazopanib
Severity: Moderate
Avapritinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is a weak to moderate CYP3A4 inhibitor and may increase avapritinib concentrations. Higher avapritinib exposure may worsen intracranial hemorrhage, cognitive effects and other toxicities.
What this interaction means in plain words
Avapritinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib by pazopanib.
What to do
Monitor for avapritinib toxicities including cognitive changes, edema and bleeding. Reduce avapritinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Pazopanib?
MediHelp rates the interaction as moderate. Avapritinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is a weak to moderate CYP3A4 inhibitor and may increase avapritinib concentrations. Higher avapritinib exposure may worsen intracranial hemorrhage, cognitive effects and other toxicities.
How serious is the interaction between Avapritinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicities including cognitive changes, edema and bleeding. Reduce avapritinib dose if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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