Drug interactions
Avapritinib + Quinine
Severity: Moderate
Avapritinib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine may modestly increase avapritinib exposure by inhibiting CYP3A4. Avapritinib has dose-related adverse effects such as cognitive effects and intracranial hemorrhage, so higher levels are undesirable.
What this interaction means in plain words
Avapritinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated avapritinib metabolism by quinine.
What to do
Monitor for avapritinib toxicity, including cognitive changes and bleeding. Consider a dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Quinine?
MediHelp rates the interaction as moderate. Avapritinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine may modestly increase avapritinib exposure by inhibiting CYP3A4. Avapritinib has dose-related adverse effects such as cognitive effects and intracranial hemorrhage, so higher levels are undesirable.
How serious is the interaction between Avapritinib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicity, including cognitive changes and bleeding. Consider a dose reduction if adverse effects emerge.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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