Drug interactions
Avapritinib + Scopolamine
Severity: Moderate
Avapritinib and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, and scopolamine can add to sedation and cognitive impairment. The combination may worsen drowsiness and confusion.
What this interaction means in plain words
Avapritinib and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Scopolamine belongs to Respiratory.
Why it happens
Additive CNS effects, including cognitive impairment and sedation.
What to do
Monitor for cognitive changes and sedation, and reconsider scopolamine use if neurocognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Scopolamine?
MediHelp rates the interaction as moderate. Avapritinib and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, and scopolamine can add to sedation and cognitive impairment. The combination may worsen drowsiness and confusion.
How serious is the interaction between Avapritinib and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes and sedation, and reconsider scopolamine use if neurocognitive effects emerge.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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