Drug interactions
Avapritinib + Tetracycline
Severity: Minor
Avapritinib and Tetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline is listed with CYP3A4 inhibitors, but it is at most a weak inhibitor clinically, so a meaningful rise in avapritinib exposure is uncertain. The interaction is largely theoretical.
What this interaction means in plain words
Avapritinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition; not well established for tetracycline.
What to do
No dose change is generally needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Tetracycline?
MediHelp rates the interaction as minor. Avapritinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline is listed with CYP3A4 inhibitors, but it is at most a weak inhibitor clinically, so a meaningful rise in avapritinib exposure is uncertain. The interaction is largely theoretical.
How serious is the interaction between Avapritinib and Tetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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