Drug interactions
Avapritinib + Vinorelbine
Severity: Minor
Avapritinib and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is not an established CYP3A4 inhibitor, so a clinically meaningful change in avapritinib exposure is unlikely. Both drugs can cause cytopenias, which may be additive.
What this interaction means in plain words
Avapritinib and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Possible weak CYP3A4 competition; no established inhibitory effect, with potential additive myelosuppression.
What to do
No dose change is routinely needed; monitor blood counts during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Vinorelbine?
MediHelp rates the interaction as minor. Avapritinib and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinorelbine is not an established CYP3A4 inhibitor, so a clinically meaningful change in avapritinib exposure is unlikely. Both drugs can cause cytopenias, which may be additive.
How serious is the interaction between Avapritinib and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor blood counts during combined therapy.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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