Drug interactions
Avelumab + Penicillin g
Severity: Minor
Avelumab and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No established mechanism or clinical evidence shows that penicillin G reduces checkpoint inhibitor efficacy. Observational data link broad-spectrum antibiotic exposure to poorer outcomes, but this is not shown for penicillin G specifically.
What this interaction means in plain words
Avelumab and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avelumab belongs to Oncology; Penicillin g belongs to Anti Bacterial.
Why it happens
Not established; hypothetically antibiotic-induced gut microbiome changes could affect immunotherapy response.
What to do
Treat infections as clinically indicated without avoiding penicillin G; avoid unnecessary antibiotic use around immunotherapy initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Avelumab
- Avelumab + Cefadroxil Moderate
- Avelumab + Cefalexin Moderate
- Avelumab + Piperacillin Moderate
- Avelumab + Piperacillin-tazobactam Moderate
Frequently asked questions
Can I take Avelumab with Penicillin g?
MediHelp rates the interaction as minor. Avelumab and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No established mechanism or clinical evidence shows that penicillin G reduces checkpoint inhibitor efficacy. Observational data link broad-spectrum antibiotic exposure to poorer outcomes, but this is not shown for penicillin G specifically.
How serious is the interaction between Avelumab and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Treat infections as clinically indicated without avoiding penicillin G; avoid unnecessary antibiotic use around immunotherapy initiation.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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