Drug interactions
Axicabtagene ciloleucel + Bevacizumab
Severity: Minor
Axicabtagene ciloleucel and Bevacizumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bevacizumab is an anti-VEGF antibody with little immunosuppressive activity, so a true additive infection risk with CAR-T therapy is not established. Bevacizumab does carry wound-healing and bleeding risks that matter around lymphodepletion and cytopenias.
What this interaction means in plain words
Axicabtagene ciloleucel and Bevacizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axicabtagene ciloleucel belongs to Oncology; Bevacizumab belongs to Oncology.
Why it happens
No established immunologic mechanism for interaction.
What to do
No specific restriction is needed. Monitor for infection, bleeding and cytopenias during CAR-T treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Bevacizumab?
MediHelp rates the interaction as minor. Axicabtagene ciloleucel and Bevacizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bevacizumab is an anti-VEGF antibody with little immunosuppressive activity, so a true additive infection risk with CAR-T therapy is not established. Bevacizumab does carry wound-healing and bleeding risks that matter around lymphodepletion and cytopenias.
How serious is the interaction between Axicabtagene ciloleucel and Bevacizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific restriction is needed. Monitor for infection, bleeding and cytopenias during CAR-T treatment.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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