Drug interactions
Axicabtagene ciloleucel + Oxaliplatin
Severity: Major
Axicabtagene ciloleucel and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin may impair CAR T-cell expansion and persistence and raise infection risk through myelosuppression.
What this interaction means in plain words
Axicabtagene ciloleucel and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive immunosuppressive and myelosuppressive effects that may impair CAR T-cell function.
What to do
Avoid chemotherapy around leukapheresis and infusion apart from the planned lymphodepletion. Monitor counts and for infection if chemotherapy follows.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Oxaliplatin?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin may impair CAR T-cell expansion and persistence and raise infection risk through myelosuppression.
How serious is the interaction between Axicabtagene ciloleucel and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chemotherapy around leukapheresis and infusion apart from the planned lymphodepletion. Monitor counts and for infection if chemotherapy follows.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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