Drug interactions
Axitinib + Calcitriol
Severity: Minor
Axitinib and Calcitriol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcitriol is described as a weak CYP3A4 inducer, which could theoretically reduce axitinib exposure. At physiologic or therapeutic calcitriol doses the clinical effect is probably small.
What this interaction means in plain words
Axitinib and Calcitriol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Calcitriol belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 induction by calcitriol, increasing axitinib metabolism; this is not well established.
What to do
No routine adjustment is needed. Monitor axitinib response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Calcitriol?
MediHelp rates the interaction as minor. Axitinib and Calcitriol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcitriol is described as a weak CYP3A4 inducer, which could theoretically reduce axitinib exposure. At physiologic or therapeutic calcitriol doses the clinical effect is probably small.
How serious is the interaction between Axitinib and Calcitriol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor axitinib response and tolerability.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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