Drug interactions
Axitinib + Darunavir
Severity: Major
Axitinib and Darunavir: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise axitinib levels. This increases the risk of hypertension, bleeding and hepatotoxicity.
What this interaction means in plain words
Axitinib and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axitinib belongs to Oncology; Darunavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition (strong with boosting) reduces axitinib metabolism.
What to do
Prefer an alternative regimen; if unavoidable, reduce axitinib dose by about half and monitor blood pressure and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Axitinib 1 mg Film-coated Tablets - SmPC sections 4.3/4.5 (class statement: strong CYP3A4/5 inhibitors; "Co-administration of axitinib with strong CYP3A4/5 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, erythromycin, atazanavir, indinavir, nefazodone,") — electronic medicines compendium (UK SmPC)
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Axitinib with Darunavir?
MediHelp rates the interaction as major. Axitinib and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise axitinib levels. This increases the risk of hypertension, bleeding and hepatotoxicity.
How serious is the interaction between Axitinib and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative regimen; if unavoidable, reduce axitinib dose by about half and monitor blood pressure and adverse effects.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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